If your name is Joel Zumaya, apparently the answer is yes. This story is back from December of 2006 but I thought it was worth a mention as Guitar Hero 2 is one of the greatest games ever made.
From engadget :
While the Wii may be getting most of the attention for video game-related injuries, it’s not the only non-conventional controller capable of causing some serious bodily harm — and as this latest incident shows, not even professional athletes are safe. When Detroit Tigers pitcher Joel Zumaya was sidelined for the first three games of the American League Championship Series earlier this year, the cause of his bad arm was kept under wraps. But now the source of his ailment has finally been revealed, with team president and general manager Dave Dombrowski telling WXYT-AM that too much Guitar Hero was to blame — after Zumaya gave up the game, his arm improved enough to pitch in the World Series. Of course, this all could have been avoided if he’d rigged up a full-size guitar for Guitar Hero instead of rocking out for hours on end with the bundled pint-sized piece of plastic that dares call itself an axe.
Since I have begun playing this game on a daily basis, my left hand is constantly achy and sore. My knuckles are at times bruised and the first few songs to warm up are always painful. The price I pay for being a rock star.
Posted by Stuicide on May 21, 2007 at 7:12 am
That game is so much fun, but I’ve hurt my left hand by playing it for a few hours one night.
For those about to rock, we salute you.
Posted by TTL Demag0gue on May 21, 2007 at 10:28 am
Hm, you’ve just given me a good reason to never pick this game up. I kind of like having my hands in good working condition, thank you very much. ;)
Posted by bsangel on May 21, 2007 at 1:04 pm
NNNOOOOO Demagogue! This game is so much fun. It is well worth the pain. You learn to work through it!
Posted by TTL Dren on May 26, 2007 at 12:32 pm
I just snagged this game last night. I almost blew through all of the easy songs last night. I doing ok and have all but 2 or 3 songs at 5 Stars. I am loving it, yet fear that fact that I will soon have to use a 4th button. Then when I get to hard I know the 5th button will mock me.
So far no injuries, yet I was a bit of a rocker when I was younger.
Dren
Posted by Waffle Deluxe on February 21, 2009 at 2:02 pm
I do think that Guitar Hero is slightly overated